In mild to moderate stages, brain regions important in memory and thinking
and planning develop more plaques and tangles than were present in early stages. As a result, individuals develop problems with memory or thinking serious enough to interfere with work or social life. They may also get confused and have trouble handling money, expressing themselves and organizing their thoughts. Many people with Alzheimer's are first diagnosed in these stages.
Plaques and tangles also spread to areas involved in:
As Alzheimer's progresses, individuals may experience changes in personality and behavior and have trouble recognizing friends and family members.